Issue 1, 2016
From the journal:

Chemical Communications

Tumor cell specific and lysosome-targeted delivery of nitric oxide for enhanced photodynamic therapy triggered by 808 nm near-infrared light†

Hui-Jing Xiang,a   Qiao Deng,a   Lu An,b   Min Guo,a   Shi-Ping Yangb  and  Jin-Gang Liu*a  

* Corresponding authors

a Key Laboratory for Advanced Materials of MOE & Department of Chemistry, East China University of Science and Technology, Shanghai, P. R. China
E-mail: liujingang@ecust.edu.cn

b Key Laboratory of Resource Chemistry of MOE & Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai, P. R. China

Abstract

A novel cancer cell lysosome-targetable multifunctional NO-delivery nanoplatform (Lyso-Ru-NO@FA@C-TiO2) (1) was developed. It selectively targets folate-receptor overexpressed cancer cells and specifically locates within the lysosome organelle to which NO and reactive oxygen species are simultaneously released upon 808 nm NIR light irradiation. The dual-targeted nanoplatform (1) demonstrated the highest anticancer efficacy compared with nontargeted counterparts under NIR light sensitization.

Graphical abstract: Tumor cell specific and lysosome-targeted delivery of nitric oxide for enhanced photodynamic therapy triggered by 808 nm near-infrared light

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Article information

DOI
https://doi.org/10.1039/C5CC07006F
Article type
Communication
Submitted
20 Aug 2015
Accepted
15 Oct 2015
First published
15 Oct 2015

Chem. Commun., 2016,52, 148-151

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Tumor cell specific and lysosome-targeted delivery of nitric oxide for enhanced photodynamic therapy triggered by 808 nm near-infrared light

H. Xiang, Q. Deng, L. An, M. Guo, S. Yang and J. Liu, Chem. Commun., 2016, 52, 148 DOI: 10.1039/C5CC07006F

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