Issue 94, 2015
From the journal:

Chemical Communications

Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser†

Jordan Atchison,a   Sukanta Kamila,a   Conor McEwan,a   Heather Nesbitt,a   James Davis,b   Colin Fowley,a   Bridgeen Callan,a   Anthony P. McHale*a  and  John F. Callan*a  

* Corresponding authors

a Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, UK
E-mail: j.callan@ulster.ac.uk

b Engineering Research Institute, University of Ulster, Jordanstown, Northern Ireland, UK

Abstract

A new sensitiser (4) for use in photodynamic therapy (PDT) has been developed to enable control of ROS production as a function of pH. This pH dependent PDT behaviour was tested in HeLa cells and in SCID mice bearing human xenograft pancreatic cancer (BxPC-3) tumours.

Graphical abstract: Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser

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Article information

DOI
https://doi.org/10.1039/C5CC07022H
Article type
Communication
Submitted
20 Aug 2015
Accepted
30 Sep 2015
First published
30 Sep 2015

Chem. Commun., 2015,51, 16832-16835

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Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser

J. Atchison, S. Kamila, C. McEwan, H. Nesbitt, J. Davis, C. Fowley, B. Callan, A. P. McHale and J. F. Callan, Chem. Commun., 2015, 51, 16832 DOI: 10.1039/C5CC07022H

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