Issue 97, 2015
From the journal:

Chemical Communications

In vivo observation of the pH alternation in mitochondria for various external stimuli†

Lixia Cao,a   Zhensheng Zhao,a   Tao Zhang,a   Xudong Guo,a   Shuangqing Wang,a   Shayu Li,*a   Yi Li*b  and  Guoqiang Yang*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: gqyang@iccas.ac.cn, shayuli@iccas.ac.cn

b Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: yili@mail.ipc.ac.cn

Abstract

The pH of mitochondria (pHm) has a close relationship with many biological processes. Here we developed a new indicator Mito-pH-1 for the ratiometric fluorescence detection of the mitochondria pH value, which has excellent tolerance to environmental change. And Mito-pH-1 has been used for the first time to monitor the change of pHm under temperature and H2O2 stimuli in living cells.

Graphical abstract: In vivo observation of the pH alternation in mitochondria for various external stimuli

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Article information

DOI
https://doi.org/10.1039/C5CC07118F
Article type
Communication
Submitted
25 Aug 2015
Accepted
05 Oct 2015
First published
06 Oct 2015

Chem. Commun., 2015,51, 17324-17327

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In vivo observation of the pH alternation in mitochondria for various external stimuli

L. Cao, Z. Zhao, T. Zhang, X. Guo, S. Wang, S. Li, Y. Li and G. Yang, Chem. Commun., 2015, 51, 17324 DOI: 10.1039/C5CC07118F

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