Issue 4, 2016

Electrochemical primer extension for the detection of single nucleotide polymorphisms in the cardiomyopathy associated MYH7 gene

Abstract

We report the labelling of dideoxy nucleotides (ddNTPs) for use in electrochemical array based primer extension for the detection of single nucleotide polymorphisms (SNPs). The results confirm the extension of the immobilised primers for each of the four ddNTPs, representing a significant advance in achieving a cost-effective platform for screening of disease-specific SNPs.

Graphical abstract: Electrochemical primer extension for the detection of single nucleotide polymorphisms in the cardiomyopathy associated MYH7 gene

Supplementary files

Article information

Article type
Communication
Submitted
16 Sep 2015
Accepted
27 Oct 2015
First published
04 Nov 2015

Chem. Commun., 2016,52, 757-759

Author version available

Electrochemical primer extension for the detection of single nucleotide polymorphisms in the cardiomyopathy associated MYH7 gene

A. M. Debela, S. Thorimbert, B. Hasenknopf, C. K. O'Sullivan and M. Ortiz, Chem. Commun., 2016, 52, 757 DOI: 10.1039/C5CC07762A

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