Issue 4, 2016

Naphthalimide-based fluorescent probe for selectively and specifically detecting glutathione in the lysosomes of living cells

Abstract

A novel naphthalimide-based fluorescent probe employing a sulfonamide unit as a thiol-responsive group is reported. It is capable of efficiently distinguishing GSH from cysteine and homocysteine. Bioimaging shows that it has high selectivity in living cells and can visualize the level of GSH in lysosomes. It is worth mentioning that different groups on the imide unit can affect the selectivity and reaction dynamics of the probe towards thiols.

Graphical abstract: Naphthalimide-based fluorescent probe for selectively and specifically detecting glutathione in the lysosomes of living cells

Supplementary files

Article information

Article type
Communication
Submitted
07 Oct 2015
Accepted
09 Nov 2015
First published
11 Nov 2015

Chem. Commun., 2016,52, 721-724

Author version available

Naphthalimide-based fluorescent probe for selectively and specifically detecting glutathione in the lysosomes of living cells

M. Cao, H. Chen, D. Chen, Z. Xu, S. H. Liu, X. Chen and J. Yin, Chem. Commun., 2016, 52, 721 DOI: 10.1039/C5CC08328A

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