Issue 10, 2016
From the journal:

Chemical Communications

All-in-One azides: empowered click reaction for in vivo labeling and imaging of biomolecules†

Yaning Su,‡ac   Li Li,‡bc   Haibin Wang,c   Xiaochen Wangc  and  Zhiyuan Zhang*cd  

* Corresponding authors

a College of Life Sciences, Beijing Normal University, Beijing 100875, China

b School of Life Sciences, Peking University, Beijing 100871, China

c National Institute of Biological Sciences (NIBS), Beijing 102206, China
E-mail: zhangzhiyuan@nibs.ac.cn

d Collaborative Innovation Center for Cancer Medicine, Beijing, China

Abstract

We designed and synthesized All-in-One (AIO) reactive azide reagents for bioorthogonal reactions with highly efficient Cu(I) ligand moieties, an azido group, and functional tags for imaging or purification. The AIO reagents displayed fast and efficient click ligation and can be applied in a wide range of in vivo systems.

Graphical abstract: All-in-One azides: empowered click reaction for in vivo labeling and imaging of biomolecules

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Article information

DOI
https://doi.org/10.1039/C5CC08466K
Article type
Communication
Submitted
12 Oct 2015
Accepted
04 Dec 2015
First published
07 Dec 2015

Chem. Commun., 2016,52, 2185-2188

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All-in-One azides: empowered click reaction for in vivo labeling and imaging of biomolecules

Y. Su, L. Li, H. Wang, X. Wang and Z. Zhang, Chem. Commun., 2016, 52, 2185 DOI: 10.1039/C5CC08466K

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