Issue 9, 2016

A tri-serine tri-lactone scaffold for the quantification of citrate in urine

Abstract

Tri-serine tri-lactone based C3 symmetry fluorescent sensors were synthesized. Citrate is shown to bind to sensors, while displaying an increase in fluorescence intensity for the sensor with thiourea and a quenching for the sensor with sulfonamide. Information-rich responses of the sensors enable us to discriminate structurally similar anions, including mono-, di- and tri-carboxylates with 100% correct classification. A simple two-sensor array enables the determination of the concentration of citrate in urine without any sample preparation with high accuracy (error < 2%).

Graphical abstract: A tri-serine tri-lactone scaffold for the quantification of citrate in urine

Supplementary files

Article information

Article type
Communication
Submitted
21 Oct 2015
Accepted
30 Nov 2015
First published
30 Nov 2015

Chem. Commun., 2016,52, 1827-1830

A tri-serine tri-lactone scaffold for the quantification of citrate in urine

A. Akdeniz, M. G. Caglayan and P. Anzenbacher, Chem. Commun., 2016, 52, 1827 DOI: 10.1039/C5CC08759G

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