Issue 11, 2016

Specific self-monitoring of metal-associated amyloid-β peptide disaggregation by a fluorescent chelator

Abstract

A dual-functional fluorescent chelator can specifically target and disassemble metal-associated Aβ aggregates and simultaneously self-monitor the disaggregation by fluorescence in brain homogenates of mice with Alzheimer's disease.

Graphical abstract: Specific self-monitoring of metal-associated amyloid-β peptide disaggregation by a fluorescent chelator

Supplementary files

Article information

Article type
Communication
Submitted
27 Oct 2015
Accepted
11 Dec 2015
First published
11 Dec 2015

Chem. Commun., 2016,52, 2245-2248

Author version available

Specific self-monitoring of metal-associated amyloid-β peptide disaggregation by a fluorescent chelator

T. Yang, X. Wang, C. Zhang, X. Ma, K. Wang, Y. Wang, J. Luo, L. Yang, C. Yao and X. Wang, Chem. Commun., 2016, 52, 2245 DOI: 10.1039/C5CC08898D

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