Issue 13, 2016

A mitochondria-targeted fluorescent probe for ratiometric detection of endogenous sulfur dioxide derivatives in cancer cells

Abstract

A new mitochondria-targeted fluorescent probe HCy-D, constructed by dansyl and hemicyanine fluorophores, for SO2 derivatives (HSO3/SO32−) was presented. This probe was designed based on a new FRET platform. HCy-D showed a ratiometric, sensitive and rapid response to HSO3/SO32−. Importantly, HCy-D was successfully used for fluorescence imaging of endogenous bisulfite in HepG2 cells, which may benefit cancer diagnosis by discriminating liver cancer cells from normal liver cells.

Graphical abstract: A mitochondria-targeted fluorescent probe for ratiometric detection of endogenous sulfur dioxide derivatives in cancer cells

Supplementary files

Article information

Article type
Communication
Submitted
02 Nov 2015
Accepted
05 Jan 2016
First published
05 Jan 2016

Chem. Commun., 2016,52, 2760-2763

A mitochondria-targeted fluorescent probe for ratiometric detection of endogenous sulfur dioxide derivatives in cancer cells

D. Li, Z. Wang, X. Cao, J. Cui, X. Wang, H. Cui, J. Miao and B. Zhao, Chem. Commun., 2016, 52, 2760 DOI: 10.1039/C5CC09092J

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