In vivo monitoring of local pH values in a live rat brain based on the design of a specific electroactive molecule for H+

Fan Zhao; Limin Zhang; Anwei Zhu; Guoyue Shi; Yang Tian

doi:10.1039/C5CC09540A

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In vivo monitoring of local pH values in a live rat brain based on the design of a specific electroactive molecule for H⁺†

Fan Zhao,^a Limin Zhang,^a Anwei Zhu,^a Guoyue Shi*^a and Yang Tian*^a

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* Corresponding authors

^a Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Dongchuan Road 500, Shanghai 200241, P. R. China
E-mail: ytian@chem.ecnu.edu.cn

Abstract

pH plays an important role in the biochemical, ion-regulatory, or electrical machinery of nerve and glial cells, and is considered to be related to a number of degenerative diseases. Herein, we first develop a two-channel electrochemical ratiometric biosensor for local pH determination in a live rat brain, and report the accurate pH values in the different regions of live brains upon global cerebral ischemia.

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Article information

DOI: https://doi.org/10.1039/C5CC09540A
Article type: Communication
Submitted: 18 Nov 2015
Accepted: 25 Jan 2016
First published: 25 Jan 2016

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Chem. Commun., 2016,52, 3717-3720

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In vivo monitoring of local pH values in a live rat brain based on the design of a specific electroactive molecule for H⁺

F. Zhao, L. Zhang, A. Zhu, G. Shi and Y. Tian, Chem. Commun., 2016, 52, 3717 DOI: 10.1039/C5CC09540A

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Chemical Communications