Issue 27, 2016

Copper-catalyzed cross-coupling reactions of epoxides with gem-diborylmethane: access to γ-hydroxyl boronic esters

Abstract

Herein, we describe a novel copper-catalyzed epoxide opening reaction with gem-diborylmethane. Aliphatic, aromatic epoxides as well as aziridines are converted to the corresponding γ-pinacolboronate alcohols or amines in moderate to excellent yields. This new reaction provides beneficial applications for classic epoxide substrates as well as interesting gem-diborylalkane reagents.

Graphical abstract: Copper-catalyzed cross-coupling reactions of epoxides with gem-diborylmethane: access to γ-hydroxyl boronic esters

Supplementary files

Article information

Article type
Communication
Submitted
27 Nov 2015
Accepted
28 Feb 2016
First published
14 Mar 2016

Chem. Commun., 2016,52, 4891-4893

Author version available

Copper-catalyzed cross-coupling reactions of epoxides with gem-diborylmethane: access to γ-hydroxyl boronic esters

A. Ebrahim-Alkhalil, Z. Zhang, T. Gong, W. Su, X. Lu, B. Xiao and Y. Fu, Chem. Commun., 2016, 52, 4891 DOI: 10.1039/C5CC09817C

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