Issue 27, 2016

Imidazolium-tagged glycan probes for non-covalent labeling of live cells

Abstract

Selective, bioorthogonal and fast labeling of glycoconjugates in living cells is a major challenge for synthetic and cellular biology. Here we report the use imidazolium tagged-mannosamine derivative (ITag-Man) for the non-covalent, rapid and site-specific labeling of sialic acid containing glycoproteins using commercial N-nitrilotriacetate fluorescent reagents in a range of cell lines.

Graphical abstract: Imidazolium-tagged glycan probes for non-covalent labeling of live cells

Supplementary files

Article information

Article type
Communication
Submitted
06 Dec 2015
Accepted
07 Mar 2016
First published
07 Mar 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 4906-4909

Author version available

Imidazolium-tagged glycan probes for non-covalent labeling of live cells

D. Benito-Alifonso, S. Tremell, J. C. Sadler, M. Berry and M. C. Galan, Chem. Commun., 2016, 52, 4906 DOI: 10.1039/C5CC10040B

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