A water-soluble and fast-response mitochondria-targeted fluorescent probe for colorimetric and ratiometric sensing of endogenously generated SO2 derivatives in living cells

Yu Liu; Kun Li; Ke-Xin Xie; Ling-Ling Li; Kang-Kang Yu; Xin Wang; Xiao-Qi Yu

doi:10.1039/C5CC10505F

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A water-soluble and fast-response mitochondria-targeted fluorescent probe for colorimetric and ratiometric sensing of endogenously generated SO₂ derivatives in living cells†

Yu Liu,^a Kun Li,*^a Ke-Xin Xie,^b Ling-Ling Li,^a Kang-Kang Yu,^a Xin Wang^a and Xiao-Qi Yu*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, P. R. China
E-mail: kli@scu.edu.cn; xqyu@scu.edu.cn
Fax: +86-28-85415886

^b Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China

Abstract

A novel water-soluble mitochondria-targeted ratiometric fluorescent probe (Cl-2) is presented. Cl-2 can respond selectively to SO₂ derivatives within 1 min. Notably, Cl-2 can be used to monitor successfully the concentration change of endogenously generated SO₂ derivatives in living cells.

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Article information

DOI: https://doi.org/10.1039/C5CC10505F
Article type: Communication
Submitted: 23 Dec 2015
Accepted: 20 Jan 2016
First published: 20 Jan 2016

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Chem. Commun., 2016,52, 3430-3433

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A water-soluble and fast-response mitochondria-targeted fluorescent probe for colorimetric and ratiometric sensing of endogenously generated SO₂ derivatives in living cells

Y. Liu, K. Li, K. Xie, L. Li, K. Yu, X. Wang and X. Yu, Chem. Commun., 2016, 52, 3430 DOI: 10.1039/C5CC10505F

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Chemical Communications