Issue 43, 2015

Quantifying transient interactions between amide groups and the guanidinium cation

Abstract

We study the interaction of the guanidinium cation, a widely used protein denaturant, with amide groups, the common structural motif of proteins. Our results provide evidence for direct contact between guanidinium and ∼2 amide groups, but the interaction is transient and weaker than for other cations with high charge-density.

Graphical abstract: Quantifying transient interactions between amide groups and the guanidinium cation

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
04 Aug 2015
Accepted
09 Oct 2015
First published
09 Oct 2015
This article is Open Access
Creative Commons BY license

Phys. Chem. Chem. Phys., 2015,17, 28539-28543

Author version available

Quantifying transient interactions between amide groups and the guanidinium cation

V. Balos, M. Bonn and J. Hunger, Phys. Chem. Chem. Phys., 2015, 17, 28539 DOI: 10.1039/C5CP04619J

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