Issue 17, 2016

Structure–mechanical property correlations of hydrogel forming β-sheet peptides

Abstract

Peptide based hydrogels have received much attention due to their potential biomedical applications. The majority of the gel forming peptides present a β-sheet motif that is composed of alternating hydrophobic/hydrophilic amino acids. Furthermore, structural characterization of the assembly of these β-sheet peptides has been refined recently. However, the relationship between peptide residue composition, molecular structure and the mechanical properties of the resulting hydrogel is not entirely understood. In this review, an analysis of the structural features of different β-sheet peptide hydrogels and their mechanical properties is discussed, in order to provide further insight on the molecular features that are relevant for the design of effective β-peptide hydrogels.

Graphical abstract: Structure–mechanical property correlations of hydrogel forming β-sheet peptides

Article information

Article type
Review Article
Submitted
25 Dec 2015
First published
15 Jun 2016

Chem. Soc. Rev., 2016,45, 4797-4824

Structure–mechanical property correlations of hydrogel forming β-sheet peptides

L. M. De Leon Rodriguez, Y. Hemar, J. Cornish and M. A. Brimble, Chem. Soc. Rev., 2016, 45, 4797 DOI: 10.1039/C5CS00941C

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