Issue 10, 2015

Enantioselective conjugate addition of cyanide to chalcones catalyzed by a magnesium-Py-BINMOL complex

Abstract

An enantioselective magnesium-catalyzed conjugate addition of trimethylsilyl cyanide to chalcones in the presence of Py-BINMOL with multiple stereogenic centers, through dual activation of substrates, has been successfully developed with moderate to good enantioselectivities and in good yields.

Graphical abstract: Enantioselective conjugate addition of cyanide to chalcones catalyzed by a magnesium-Py-BINMOL complex

Supplementary files

Article information

Article type
Communication
Submitted
12 Jul 2015
Accepted
12 Aug 2015
First published
17 Aug 2015

Catal. Sci. Technol., 2015,5, 4755-4759

Author version available

Enantioselective conjugate addition of cyanide to chalcones catalyzed by a magnesium-Py-BINMOL complex

C. Dong, T. Song, X. Bai, Y. Cui, Z. Xu and L. Xu, Catal. Sci. Technol., 2015, 5, 4755 DOI: 10.1039/C5CY01056J

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