Catalytic functionalization of low reactive C(sp3)–H and C(sp2)–H bonds of alkanes and arenes by carbene transfer from diazo compounds

Abstract

The direct functionalization of low reactive C(sp³)–H and C(sp²)–H bonds of alkanes and arenes, respectively, by metal-induced carbene transfer from diazo compounds is reviewed. To date, this methodology has enabled the incorporation of CR¹R² moieties from N₂CR¹R² in a chemo, regio, enantio or diastereoselective manner in those substrates with the appropriate selection of metal and ligands.