Issue 6, 2015
From the journal:

Green Chemistry

Enzyme cascade reactions: synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem†

Shane M. McKenna,a   Silke Leimkühler,b   Susanne Herter,c   Nicholas J. Turner*c  and  Andrew J. Carnell*a  

* Corresponding authors

a Department of Chemistry, University of Liverpool, Crown Street, Liverpool, UK
E-mail: acarnell@liv.ac.uk
Fax: +44 (0)151 7943500
Tel: +44 (0)151 7943534

b Institute of Biochemistry and Biology, University of Potsdam, D-14476 Potsdam, Germany
E-mail: sleim@uni-potsdam.de
Fax: +44 331/977-5128
Tel: +49 331/977-5603

c School of Chemistry, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, UK
E-mail: nicholas.turner@manchester.ac.uk
Fax: +44 (0)161 2751311
Tel: +44 (0)161 3065173

Abstract

A one-pot tandem enzyme reaction using galactose oxidase M3–5 and aldehyde oxidase PaoABC was used to convert hydroxymethylfurfural (HMF) to the pure bioplastics precursor FDCA in 74% isolated yield. A range of alcohols was also converted to carboxylic acids in high yield under mild conditions.

Graphical abstract: Enzyme cascade reactions: synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem

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Article information

DOI
https://doi.org/10.1039/C5GC00707K
Article type
Communication
Submitted
01 Apr 2015
Accepted
21 Apr 2015
First published
21 Apr 2015

Green Chem., 2015,17, 3271-3275

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Enzyme cascade reactions: synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem

S. M. McKenna, S. Leimkühler, S. Herter, N. J. Turner and A. J. Carnell, Green Chem., 2015, 17, 3271 DOI: 10.1039/C5GC00707K

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