Issue 8, 2015

Eco-friendly chemoselective N-functionalization of isatins mediated by supported KF in 2-MeTHF

Abstract

A sustainable, efficient method for the chemoselective N-functionalization of isatins based on the use of KF-Celite in 2-methyltetrahydrofuran is reported. Notably, the protocol allows reactions with a wide range of electrophiles such as alkyl halides, isocyanates and Michael acceptors.

Graphical abstract: Eco-friendly chemoselective N-functionalization of isatins mediated by supported KF in 2-MeTHF

Supplementary files

Article information

Article type
Communication
Submitted
11 May 2015
Accepted
07 Jul 2015
First published
08 Jul 2015

Green Chem., 2015,17, 4194-4197

Eco-friendly chemoselective N-functionalization of isatins mediated by supported KF in 2-MeTHF

A. D. Mamuye, S. Monticelli, L. Castoldi, W. Holzer and V. Pace, Green Chem., 2015, 17, 4194 DOI: 10.1039/C5GC01002K

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