Issue 6, 2015
From the journal:

MedChemComm

A novel aminotriazole-based NHC complex for the design of gold(i) anti-cancer agents: synthesis and biological evaluation†

T. V. Serebryanskaya,*ac   A. A. Zolotarevb  and  I. Ott*a  

* Corresponding authors

a Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106 Braunschweig, Germany
E-mail: ingo.ott@tu-bs.de

b Institute of Earth Sciences, Saint Petersburg State University, University Emb. 7/9, 199034 Saint Petersburg, Russian Federation

c Institute of Chemistry, Saint Petersburg State University, Universitetsky Pr. 26, 198504 Stary Petergof, Russian Federation
E-mail: t.serebryanskaya@chem.spbu.ru

Abstract

A novel gold(I) complex based on an aminotriazole N-heterocylic carbene ligand represents a promising scaffold for the design of anticancer bioorganometallics. The complex triggered cytotoxic effects in HT-29 and MDA-MB-231 cancer cells, inhibited the activity of the enzyme thioredoxin reductase and showed an effective and fast cellular accumulation.

Graphical abstract: A novel aminotriazole-based NHC complex for the design of gold(i) anti-cancer agents: synthesis and biological evaluation

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Article information

DOI
https://doi.org/10.1039/C5MD00185D
Article type
Concise Article
Submitted
28 Apr 2015
Accepted
12 May 2015
First published
13 May 2015
This article is Open Access
Creative Commons BY-NC license

Med. Chem. Commun., 2015,6, 1186-1189

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A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation

T. V. Serebryanskaya, A. A. Zolotarev and I. Ott, Med. Chem. Commun., 2015, 6, 1186 DOI: 10.1039/C5MD00185D

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