Issue 5, 2016
From the journal:

MedChemComm

Significantly improving the solubility of non-steroidal anti-inflammatory drugs in deep eutectic solvents for potential non-aqueous liquid administration†‡

Chao Lu,a   Jun Cao,a   Ning Wanga  and  Erzheng Su*abc  

* Corresponding authors

a Enzyme and Fermentation Technology Laboratory, College of Light Industry Science and Engineering, Nanjing Forestry University, Nanjing 210037, China
E-mail: ezhsu@njfu.edu.cn
Tel: +86 25 85428906

b State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China

c State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China

Abstract

Deep eutectic solvents (DESs) are a new class of green solvents used to dissolve non-steroidal anti-inflammatory drugs (NSAIDs) for potential non-aqueous liquid administration applications. Several NSAIDs are readily soluble in various DESs to a high concentration. Aspirin, a hydrolabile NSAID, was 8.2-fold more stable against cleavage in DES than in water.

Graphical abstract: Significantly improving the solubility of non-steroidal anti-inflammatory drugs in deep eutectic solvents for potential non-aqueous liquid administration

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Article information

DOI
https://doi.org/10.1039/C5MD00551E
Article type
Research Article
Submitted
29 Nov 2015
Accepted
26 Feb 2016
First published
29 Feb 2016

Med. Chem. Commun., 2016,7, 955-959

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Significantly improving the solubility of non-steroidal anti-inflammatory drugs in deep eutectic solvents for potential non-aqueous liquid administration

C. Lu, J. Cao, N. Wang and E. Su, Med. Chem. Commun., 2016, 7, 955 DOI: 10.1039/C5MD00551E

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