Issue 8, 2015

Enzyme responsive mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo

Abstract

This study reports a biocompatible controlled drug release system based on mesoporous silica nanoparticles (MSNs) for tumor microenvironment responsive drug delivery. It was fabricated by grafting phenylboronic acid conjugated human serum albumin (PBA-HSA) onto the surfaces of MSNs as a sealing agent, via an intermediate linker of a functional polypeptide, which was composed of two functional units: the polycation cell penetrating peptide (CPP) polyarginine, and matrix metalloproteinase 2 (MMP-2) substrate peptide. A series of characterizations confirmed that the system had been successfully constructed. In vitro tests proved that the anticancer drug loading system could efficiently induce cell apoptosis in vitro. More importantly, the in vivo tumor experiments confirmed that the anticancer loading system could efficiently inhibit tumor growth with minimal side effects.

Graphical abstract: Enzyme responsive mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo

Supplementary files

Article information

Article type
Paper
Submitted
06 Jan 2015
Accepted
07 Jan 2015
First published
08 Jan 2015

Nanoscale, 2015,7, 3614-3626

Enzyme responsive mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo

J. Liu, B. Zhang, Z. Luo, X. Ding, J. Li, L. Dai, J. Zhou, X. Zhao, J. Ye and K. Cai, Nanoscale, 2015, 7, 3614 DOI: 10.1039/C5NR00072F

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