Issue 21, 2015
From the journal:

Nanoscale

DNA hydrogel delivery vehicle for light-triggered and synergistic cancer therapy†

Jaejung Song,a   Kyuhyun Im,b   Sekyu Hwang,c   Jaehyun Hur,d   Jutaek Nam,c   G-One Ahn,e   Sungwoo Hwang,b   Sungjee Kim*ac  and  Nokyoung Park*f  

* Corresponding authors

a School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science & Technology (POSTECH), San 31, Hyojadong, Pohang 790-784, Korea
E-mail: sungjee@postech.ac.kr
Tel: +82-54-279-2108

b Samsung Advanced Institute of Technology, Samsung Electronics, Yongin, Gyeonggi-do, Korea

c Department of Chemistry, POSTECH, Korea

d Department of Chemical and Biological Engineering, Gachon University, Seongnam, Gyeonggi-do, Korea

e Division of Integrative Biosciences and Biotechnology, POSTECH, Korea

f Department of Chemistry, Myongji University, Yongin, Gyeonggi-do 449-728, Korea
E-mail: pospnk@mju.ac.kr
Tel: +82-31-330-6188

Abstract

A DNA hydrogel is reported as a delivery vehicle for gold nanorods and doxorubicin. The two photothermal and chemo cancer agents were co-loaded using electrostatic and DNA binding interactions, respectively. Light-triggered and highly synergistic combination cancer therapy was demonstrated in cellular and animal models.

Graphical abstract: DNA hydrogel delivery vehicle for light-triggered and synergistic cancer therapy

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Article information

DOI
https://doi.org/10.1039/C5NR00858A
Article type
Communication
Submitted
06 Feb 2015
Accepted
21 Apr 2015
First published
11 May 2015
This article is Open Access
Creative Commons BY license

Nanoscale, 2015,7, 9433-9437

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DNA hydrogel delivery vehicle for light-triggered and synergistic cancer therapy

J. Song, K. Im, S. Hwang, J. Hur, J. Nam, G. Ahn, S. Hwang, S. Kim and N. Park, Nanoscale, 2015, 7, 9433 DOI: 10.1039/C5NR00858A

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