Issue 14, 2015

Two-dimensional TiS2 nanosheets for in vivo photoacoustic imaging and photothermal cancer therapy

Abstract

Recently, transition metal dichalcogenides (TMDCs) have attracted significant attention in nanomedicine owing to their intriguing properties. In this study, TiS2 nanosheets, a new TMDC nanomaterial, are synthesized by a bottom-up solution-phase method and then modified with polyethylene glycol (PEG), obtaining TiS2-PEG with high stability in physiological solutions and no appreciable in vitro toxicity. Due to their high absorbance in the near-infrared (NIR) region, TiS2-PEG nanosheets could offer a strong contrast in photoacoustic imaging, which uncovers the high tumor uptake and retention of these nanosheets after systemic administration into tumor-bearing mice. We further apply TiS2-PEG nanosheets for in vivo photothermal therapy, which are able to completely eradicate the tumors in mice upon intravenous injection of TiS2-PEG followed by NIR laser irradiation. Our work indicates that TiS2 nanosheets with appropriate surface coating (e.g. PEGylation) would be a promising new class of photothermal agents for imaging-guided cancer therapy.

Graphical abstract: Two-dimensional TiS2 nanosheets for in vivo photoacoustic imaging and photothermal cancer therapy

Supplementary files

Article information

Article type
Paper
Submitted
07 Feb 2015
Accepted
08 Mar 2015
First published
09 Mar 2015

Nanoscale, 2015,7, 6380-6387

Author version available

Two-dimensional TiS2 nanosheets for in vivo photoacoustic imaging and photothermal cancer therapy

X. Qian, S. Shen, T. Liu, L. Cheng and Z. Liu, Nanoscale, 2015, 7, 6380 DOI: 10.1039/C5NR00893J

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