Issue 17, 2015
From the journal:

Nanoscale

Recording the dynamic endocytosis of single gold nanoparticles by AFM-based force tracing†

Bohua Ding,‡a   Yongmei Tian,‡bc   Yangang Pan,bc   Yuping Shan,b   Mingjun Cai,b   Haijiao Xu,b   Yingchun Sun*a  and  Hongda Wang*bc  

* Corresponding authors

a School of Physics, Northeast Normal University, Changchun, Jilin 130024, P.R. China
E-mail: sunyc149@nenu.edu.cn

b State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P.R. China
E-mail: hdwang@ciac.ac.cn

c University of Chinese Academy of Sciences, Beijing, China

Abstract

We utilized force tracing to directly record the endocytosis of single gold nanoparticles (Au NPs) with different sizes, revealing the size-dependent endocytosis dynamics and the crucial role of membrane cholesterol. The force, duration and velocity of Au NP invagination are accurately determined at the single-particle and microsecond level unprecedentedly.

Graphical abstract: Recording the dynamic endocytosis of single gold nanoparticles by AFM-based force tracing

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Article information

DOI
https://doi.org/10.1039/C5NR01020A
Article type
Communication
Submitted
12 Feb 2015
Accepted
31 Mar 2015
First published
02 Apr 2015

Nanoscale, 2015,7, 7545-7549

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Recording the dynamic endocytosis of single gold nanoparticles by AFM-based force tracing

B. Ding, Y. Tian, Y. Pan, Y. Shan, M. Cai, H. Xu, Y. Sun and H. Wang, Nanoscale, 2015, 7, 7545 DOI: 10.1039/C5NR01020A

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