Issue 21, 2015

Design and assembly of supramolecular dual-modality nanoprobes

Abstract

We report the design and synthesis of self-assembling dual-modality molecular probes containing both a fluorophore for optical imaging and a metal ion chelator for imaging with MRI or radionuclide methods. These molecular probes can spontaneously associate into spherical nanoparticles under physiological conditions. We demonstrate the use of these supramolecular nanoprobes for live-cell optical imaging, as well as their potential use as MRI contrast agents after complexation with gadolinium. Our results suggest that self-assembly into supramolecular nanoprobes presents an effective means to enhance and tune the relaxivities of molecular probes.

Graphical abstract: Design and assembly of supramolecular dual-modality nanoprobes

Supplementary files

Article information

Article type
Communication
Submitted
09 Mar 2015
Accepted
25 Apr 2015
First published
28 Apr 2015

Nanoscale, 2015,7, 9462-9466

Author version available

Design and assembly of supramolecular dual-modality nanoprobes

S. Liu, P. Zhang, S. Ray Banerjee, J. Xu, M. G. Pomper and H. Cui, Nanoscale, 2015, 7, 9462 DOI: 10.1039/C5NR01518A

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