Issue 28, 2015

A dual wavelength-activatable gold nanorod complex for synergistic cancer treatment

Abstract

A multifunctional gold nanorod (AuNR) complex is described with potential utility for theranostic anticancer treatment. The AuNR was functionalized with cyclodextrin for encapsulation of doxorubicin, with folic acid for targeting, and with a photo-responsive dextran-azo compound for intracellular controlled drug release. The interaction of a AuNR complex with HeLa cells was facilitated via a folic acid targeting ligand as displayed in the dark-field images of cells. Enhanced anticancer efficacy was demonstrated through the synergistic combination of promoted drug release upon ultraviolet (UV) light irradiation and photothermal therapy upon infrared (IR) irradiation. This multifunctional AuNR-based system represents a novel theranostic strategy for spatiotemporal delivery of anticancer therapeutics.

Graphical abstract: A dual wavelength-activatable gold nanorod complex for synergistic cancer treatment

Supplementary files

Article information

Article type
Paper
Submitted
10 Mar 2015
Accepted
01 Apr 2015
First published
30 Jun 2015

Nanoscale, 2015,7, 12096-12103

Author version available

A dual wavelength-activatable gold nanorod complex for synergistic cancer treatment

D. B. Pacardo, B. Neupane, S. M. Rikard, Y. Lu, R. Mo, S. R. Mishra, J. B. Tracy, G. Wang, F. S. Ligler and Z. Gu, Nanoscale, 2015, 7, 12096 DOI: 10.1039/C5NR01568E

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