Issue 17, 2015

Copper-catalysed cross-coupling: an untapped potential

Abstract

Copper is emerging as a viable catalytic metal for cross-coupling reactions to construct carbon–carbon (C–C) bonds. Recent revelations that Cu-catalysts can execute with high efficacy the cross-couplings of a variety of organometallic reagents, including organomagnesium, organoboron, organosilicon, organoindium and organomanganese, with alkyl, aryl and heteroaryl halides clearly demonstrate the versatility of Cu-based catalytic systems in conducting these reactions. In addition, Cu-catalysts are exhibiting a unique reactivity pattern that allows ligandless cross-coupling for aryl–heteroaryl and heteroaryl–heteroaryl bond formation, a transformation that generally requires special custom-designed ligands with Pd-catalysts. This review summarises early discoveries and subsequent advancements made in the area of Cu-catalysed cross-couplings of organometallic reagents with organohalides to form C–C bonds.

Graphical abstract: Copper-catalysed cross-coupling: an untapped potential

Article information

Article type
Review Article
Submitted
31 Jan 2015
Accepted
19 Mar 2015
First published
19 Mar 2015

Org. Biomol. Chem., 2015,13, 4816-4827

Author version available

Copper-catalysed cross-coupling: an untapped potential

S. Thapa, B. Shrestha, S. K. Gurung and R. Giri, Org. Biomol. Chem., 2015, 13, 4816 DOI: 10.1039/C5OB00200A

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