Issue 21, 2015

Synthesis of multiply substituted 1,6-dihydropyridines through Cu(i)-catalyzed 6-endo cyclization

Abstract

Copper-catalyzed 6-endo cyclization of N-propargylic β-enaminocarbonyls was developed for the synthesis of oxidation-labile 1,6-dihydropyridines. This synthetic method allows flexible and regio-defined assembly of various substituents at the N1, C2, C3, C4, and C6 positions of 1,6-dihydropyridines under mild conditions.

Graphical abstract: Synthesis of multiply substituted 1,6-dihydropyridines through Cu(i)-catalyzed 6-endo cyclization

Supplementary files

Article information

Article type
Paper
Submitted
21 Feb 2015
Accepted
20 Apr 2015
First published
21 Apr 2015

Org. Biomol. Chem., 2015,13, 5955-5963

Author version available

Synthesis of multiply substituted 1,6-dihydropyridines through Cu(I)-catalyzed 6-endo cyclization

H. Mizoguchi, R. Watanabe, S. Minami, H. Oikawa and H. Oguri, Org. Biomol. Chem., 2015, 13, 5955 DOI: 10.1039/C5OB00356C

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