Issue 21, 2015
From the journal:

Organic & Biomolecular Chemistry

The synthesis of new amphiphilic p-tert-butylthiacalix[4]arenes containing peptide fragments and their interaction with DNA†

Pavel L. Padnya,a   Elena A. Andreyko,a   Olga A. Mostovaya,a   Ildar Kh. Rizvanovb  and  Ivan I. Stoikov*a  

* Corresponding authors

a Kazan (Volga Region) Federal University, A.M. Butlerov Chemical Institute, 420008 Kremlevskaya, 18, Kazan, Russian Federation
E-mail: Ivan.Stoikov@mail.ru
Fax: +7-8432-752253
Tel: +7-8432-337463

b A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Centre of the Russian Academy of Sciences, 420088 Kazan, Russian Federation

Abstract

New water-soluble p-tert-butylthiacalix[4]arenes containing peptide and quaternary ammonium fragments in cone and 1,3-alternate conformations were synthesized and characterized. The interaction of the macrocycles with DNA was studied by UV-spectroscopy, DLS and TEM. It was shown that the interaction of the self-associates based on p-tert-butylthiacalix[4]arenes tetrasubstituted at the lower rim with glycine and quaternary ammonium fragments in cone and 1,3-alternate conformations with DNA led to the formation of particles of about 99–192 nm in size.

Graphical abstract: The synthesis of new amphiphilic p-tert-butylthiacalix[4]arenes containing peptide fragments and their interaction with DNA

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Article information

DOI
https://doi.org/10.1039/C5OB00548E
Article type
Paper
Submitted
18 Mar 2015
Accepted
15 Apr 2015
First published
15 Apr 2015

Org. Biomol. Chem., 2015,13, 5894-5904

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The synthesis of new amphiphilic p-tert-butylthiacalix[4]arenes containing peptide fragments and their interaction with DNA

P. L. Padnya, E. A. Andreyko, O. A. Mostovaya, I. Kh. Rizvanov and I. I. Stoikov, Org. Biomol. Chem., 2015, 13, 5894 DOI: 10.1039/C5OB00548E

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