Issue 26, 2015
From the journal:

Organic & Biomolecular Chemistry

Benzyllithiums bearing aldehyde carbonyl groups. A flash chemistry approach†

Aiichiro Nagaki,a   Yuta Tsuchihashi,a   Suguru Harakia  and  Jun-ichi Yoshida*a  

* Corresponding authors

a Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, Japan
E-mail: yoshida@sbchem.kyoto-u.ac.jp

Abstract

Reductive lithiation of benzyl halides bearing aldehyde carbonyl groups followed by reaction with subsequently added electrophiles was successfully accomplished without affecting the carbonyl groups by taking advantage of short residence times in flow microreactors.

Graphical abstract: Benzyllithiums bearing aldehyde carbonyl groups. A flash chemistry approach

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Article information

DOI
https://doi.org/10.1039/C5OB00958H
Article type
Communication
Submitted
12 May 2015
Accepted
21 May 2015
First published
09 Jun 2015
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2015,13, 7140-7145

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Benzyllithiums bearing aldehyde carbonyl groups. A flash chemistry approach

A. Nagaki, Y. Tsuchihashi, S. Haraki and J. Yoshida, Org. Biomol. Chem., 2015, 13, 7140 DOI: 10.1039/C5OB00958H

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