Issue 36, 2015

Total synthesis of the natural product EBC-329

Abstract

The first total synthesis of an anti-leukemic diterpene natural product EBC-329 (1) has been accomplished starting from readily available 6,6-dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione (7). An efficient and general approach has been reported for the synthesis of EBC-329 in 13 steps with an overall yield of 10%.

Graphical abstract: Total synthesis of the natural product EBC-329

Supplementary files

Article information

Article type
Paper
Submitted
23 Jun 2015
Accepted
29 Jul 2015
First published
30 Jul 2015

Org. Biomol. Chem., 2015,13, 9485-9491

Total synthesis of the natural product EBC-329

R. S. Thombal and V. H. Jadhav, Org. Biomol. Chem., 2015, 13, 9485 DOI: 10.1039/C5OB01276G

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