An economical synthesis of substituted quinoline-2-carboxylates through the potassium persulfate-mediated cross-dehydrogenative coupling of N-aryl glycine derivatives with olefins

Abstract

A practical and economical K₂S₂O₈-mediated oxidative cross-dehydrogenative coupling of N-aryl glycine derivatives with olefins has been established, affording structurally diverse quinoline-2-carboxylates in good to high efficiency. The low cost, negligible toxicity, and ease of handling of K₂S₂O₈ combined with the absence of hazardous byproducts and the easy workup consisting of simple filtration are attractive based on economic and environmental factors.