Issue 5, 2016

Iron-catalyzed direct α-arylation of α-amino carbonyl compounds with indoles

Abstract

A mild and general α-arylation of α-amino carbonyls with indoles catalyzed by Fe(ClO4)3 has been developed. C–H activation is smoothly fulfilled by using TBHP as the oxidant with good yields. Two hydrogen dissociations make this transformation more environmentally benign because of high atom efficiency.

Graphical abstract: Iron-catalyzed direct α-arylation of α-amino carbonyl compounds with indoles

Supplementary files

Article information

Article type
Communication
Submitted
12 Nov 2015
Accepted
23 Dec 2015
First published
23 Dec 2015

Org. Biomol. Chem., 2016,14, 1550-1554

Iron-catalyzed direct α-arylation of α-amino carbonyl compounds with indoles

Y. Zhang, M. Ni and B. Feng, Org. Biomol. Chem., 2016, 14, 1550 DOI: 10.1039/C5OB02325D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements