Issue 4, 2016

Copper-catalyzed C–H ethoxycarbonyldifluoromethylation of imidazoheterocycles

Abstract

A regioselective copper-catalyzed ethoxycarbonyl-difluoromethylation of imidazo[1,2-a]pyridines has been developed through sp2 C–H bond functionalization with BrCF2CO2Et under ambient air. A series of ethoxycarbonyldifluoromethylated imidazo[1,2-a]pyridines with broad functionalities have been synthesized. This methodology is also applicable to imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole.

Graphical abstract: Copper-catalyzed C–H ethoxycarbonyldifluoromethylation of imidazoheterocycles

Supplementary files

Article information

Article type
Paper
Submitted
17 Nov 2015
Accepted
09 Dec 2015
First published
10 Dec 2015

Org. Biomol. Chem., 2016,14, 1432-1436

Copper-catalyzed C–H ethoxycarbonyldifluoromethylation of imidazoheterocycles

S. Mishra, P. Mondal, M. Ghosh, S. Mondal and A. Hajra, Org. Biomol. Chem., 2016, 14, 1432 DOI: 10.1039/C5OB02363G

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