Copper-catalyzed decarboxylative cross-coupling of cinnamic acids and ACCN via single electron transfer

Abstract

A novel and convenient method for the synthesis of β,γ-unsaturated nitriles using ACCN (1,1′-azobis(cyclohexane-1-carbonitrile)) as a cyano source was described. This reaction was amenable to a broad range of substrates and provided the desired β,γ-unsaturated nitriles containing an all-carbon quaternary carbon center in moderate yields with high selectivity via single electron transfer and decarboxylation.