Issue 10, 2015

Photodynamic therapy (PDT) of cancer: from local to systemic treatment

Abstract

Photodynamic therapy (PDT) requires a medical device, a photosensitizing drug and adequate use of both to trigger biological mechanisms that can rapidly destroy the primary tumour and provide long-lasting protection against metastasis. We present a multidisciplinary view of the issues raised by the development of PDT. We show how spectroscopy, photophysics, photochemistry and pharmacokinetics of photosensitizers determine the mechanism of cell death and clinical protocols. Various examples of combinations with chemotherapies and immunotherapies illustrate the opportunities to potentiate the outcome of PDT. Particular emphasis is given to the mechanisms that can be exploited to establish PDT as a systemic treatment of solid tumours and metastatic disease.

Graphical abstract: Photodynamic therapy (PDT) of cancer: from local to systemic treatment

Article information

Article type
Perspective
Submitted
31 Mar 2015
Accepted
06 Jul 2015
First published
10 Jul 2015

Photochem. Photobiol. Sci., 2015,14, 1765-1780

Author version available

Photodynamic therapy (PDT) of cancer: from local to systemic treatment

J. M. Dąbrowski and L. G. Arnaut, Photochem. Photobiol. Sci., 2015, 14, 1765 DOI: 10.1039/C5PP00132C

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