Issue 32, 2015

Preparation of biocompatible and photostable PEGylated red fluorescent nanoparticles for cellular imaging

Abstract

PEGylated red fluorescent nanoparticles with excellent biocompatibility and photostablity were facilely prepared from nonluminous materials: first red fluorescent nanoparticles (GCC NPs) were robustly prepared from chitosan and glutaraldehyde; then the amino groups and hydroxyl groups on the GCC NP surfaces were modified with 2-bromoisobutyryl bromide to obtain GCC-Br, which was employed as the nanoparticles’ initiator in the ATRP system to finally obtain the GCC–poly(PEGMA) conjugates. The resulting GCC–poly(PEGMA) can emit a biofavorable deep red luminescence, which is quite stable and anti-photobleaching. Furthermore, GCC–poly(PEGMA) demonstrated excellent biocompatibility and water dispersibility due to the PEGMA chains conjugated on the surface; and the abundant hydroxyl groups on the surface can be further functionalized with diverse other groups or large biomolecules. This construction method demonstrated great advantages due to its simple strategy and economic value, and the NPs’ successful cellular imaging endows them with a lot of potential for various biomedical applications.

Graphical abstract: Preparation of biocompatible and photostable PEGylated red fluorescent nanoparticles for cellular imaging

Supplementary files

Article information

Article type
Paper
Submitted
16 Jun 2015
Accepted
26 Jun 2015
First published
30 Jun 2015

Polym. Chem., 2015,6, 5891-5898

Preparation of biocompatible and photostable PEGylated red fluorescent nanoparticles for cellular imaging

K. Wang, X. Zhang, X. Zhang, X. Fan, Z. Huang, Y. Chen and Y. Wei, Polym. Chem., 2015, 6, 5891 DOI: 10.1039/C5PY00929D

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