Issue 7, 2015

Transition-metal free oxidative aliphatic C–H fluorination

Abstract

A practical and highly selective fluorination of unactivated aliphatic C–H bonds without the use of transition metals has been developed. This C–H fluorination protocol is robust, operationally simple, scalable and compatible with moisture and air. Furthermore, the method exhibits a broad substrate scope and is applicable to late-stage fluorination of natural products and derivatives, which make it a valuable method for the synthesis of fluorinated complex molecules.

Graphical abstract: Transition-metal free oxidative aliphatic C–H fluorination

Supplementary files

Article information

Article type
Research Article
Submitted
25 Mar 2015
Accepted
15 Apr 2015
First published
16 Apr 2015

Org. Chem. Front., 2015,2, 806-810

Transition-metal free oxidative aliphatic C–H fluorination

X. Zhang, S. Guo and P. Tang, Org. Chem. Front., 2015, 2, 806 DOI: 10.1039/C5QO00095E

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