Issue 34, 2015

Self-assembly of l-cysteine–gold nanoparticles as chiral probes for visual recognition of 3,4-dihydroxyphenylalanine enantiomers

Abstract

A simple protocol to distinguish enantiomers is extremely intriguing and useful. Herein, we report on a method for the visual recognition of 3,4-dihydroxyphenylalanine (Dopa) enantiomers. It is based on the chirality of L-cysteine-capped gold nanoparticles (L-Cys-capped AuNPs) that can be used as a chiral selector for L- and D- forms of Dopa. On addition of L-Dopa to a solution of the L-Cys-capped AuNPs, a color change from red to blue can be seen, while no color change is found on addition of D-Dopa. The chiral recognition can be achieved by eye and simple spectrophotometry. Notably, this method does not require complicated chiral modification. The method excels through its low-cost, good availability of materials, and its simplicity.

Graphical abstract: Self-assembly of l-cysteine–gold nanoparticles as chiral probes for visual recognition of 3,4-dihydroxyphenylalanine enantiomers

Supplementary files

Article information

Article type
Paper
Submitted
22 Jan 2015
Accepted
11 Mar 2015
First published
11 Mar 2015

RSC Adv., 2015,5, 27003-27008

Self-assembly of L-cysteine–gold nanoparticles as chiral probes for visual recognition of 3,4-dihydroxyphenylalanine enantiomers

L. Zhang, C. Xu, G. Song and B. Li, RSC Adv., 2015, 5, 27003 DOI: 10.1039/C5RA01271F

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