Meglumine catalyzed one-pot, three-component combinatorial synthesis of pyrazoles bearing a coumarin unit

Abstract

A simple, efficient, and eco-friendly procedure for the synthesis of a wide range of pyrazoles bearing a coumarin unit has been developed using a one-pot three-component reaction of salicylaldehyde, 4-hydroxy-6-methyl-2H-pyran-2-one, and hydrazine using meglumine as a catalyst in aqueous–ethanol media. This new protocol offers several advantages including the use of a biodegradable and inexpensive catalyst, short reaction time, high yields, and simple work-up procedure.