Issue 49, 2015

The effect of submicron bioactive glass particles on in vitro osteogenesis

Abstract

This study investigated the effects of novel submicron bioactive glass (sm-BG) particles on in vitro osteogenesis and compared them to those of microscale bioactive glass (m-BG) particles. The ability of sm-BG particles to generate precipitates on their surface in the presence of simulated body fluid (SBF) was examined, and the effect of sm-BG particles on in vitro osteogenesis was evaluated by culturing human osteoblast-like osteosarcoma (MG-63) cells on particle-coated plates. It was found that sm-BG induced formation of precipitates after incubation for 24 hours in SBF. Compared with m-BG, sm-BG particles better promoted MG-63 cell adhesion and they induced expression of the ALP, RUNX2 and COL1 genes at an earlier stage and to a greater degree. This study demonstrates that submicron bioactive glass particles possess a high capacity for precipitates formation in SBF and improved osteogenic properties when compared to microscale BG particles.

Graphical abstract: The effect of submicron bioactive glass particles on in vitro osteogenesis

Article information

Article type
Paper
Submitted
03 Mar 2015
Accepted
21 Apr 2015
First published
21 Apr 2015

RSC Adv., 2015,5, 38830-38836

The effect of submicron bioactive glass particles on in vitro osteogenesis

S. Liu, W. Gong, Y. Dong, Q. Hu, X. Chen and X. Gao, RSC Adv., 2015, 5, 38830 DOI: 10.1039/C5RA03786G

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