Issue 38, 2015

Developmental and organ-specific toxicity of cucurbit[7]uril: in vivo study on zebrafish models

Abstract

The macrocyclic molecular container cucurbit[7]uril (CB[7]), the most water-soluble homologue in the cucurbit[n]uril family (n = 5–8, 10, 14), has been evaluated for its in vivo toxicity profile, including its developmental toxicity such as its effect on hatching, growth and survival, as well as its potential organ-specific toxicities such as cardiotoxicity, hepatotoxicity, and locomotion and behavioral toxicity, using zebrafish models. The results revealed that CB[7] has measureable cardiotoxicity and locomotion and behavioral toxicity at concentrations of ∼500 μM or higher, and negligible developmental and hepatotoxicity at concentrations up to 750 μM, although extended exposure to CB[7] in the 500–750 μM concentration range induced the mortality of tested fish. These results demonstrate for the first time with live in vivo animal models that CB[7] has relatively low developmental and organic specific toxicity, and support further exploration of the use of CB[7] in biomedical research at sub-toxic concentrations.

Graphical abstract: Developmental and organ-specific toxicity of cucurbit[7]uril: in vivo study on zebrafish models

Supplementary files

Article information

Article type
Paper
Submitted
11 Mar 2015
Accepted
23 Mar 2015
First published
23 Mar 2015
This article is Open Access
Creative Commons BY license

RSC Adv., 2015,5, 30067-30074

Author version available

Developmental and organ-specific toxicity of cucurbit[7]uril: in vivo study on zebrafish models

H. Chen, J. Y. W. Chan, X. Yang, I. W. Wyman, D. Bardelang, D. H. Macartney, S. M. Y. Lee and R. Wang, RSC Adv., 2015, 5, 30067 DOI: 10.1039/C5RA04335B

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