Mn(OAc)3-mediated arylation–lactonization of alkenoic acids: synthesis of γ,γ-disubstituted butyrolactones

Yuzhen Gao; Jian Xu; Pengbo Zhang; Hua Fang; Guo Tang; Yufen Zhao

doi:10.1039/C5RA04429D

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Mn(OAc)₃-mediated arylation–lactonization of alkenoic acids: synthesis of γ,γ-disubstituted butyrolactones†

Yuzhen Gao,^a Jian Xu,^a Pengbo Zhang,^a Hua Fang,^b Guo Tang*^a and Yufen Zhao^a

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* Corresponding authors

^a Department of Chemistry, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, China
E-mail: t12g21@xmu.edu.cn
Fax: +86-592-2185780

^b Third Institute of Oceanography, State Oceanic Administration, Xiamen, Fujian 361005, China

Abstract

A general method for the oxidative cyclization of 4-alkenoic acids with arylboronic acids has been developed. The reactions described provide a novel access to γ,γ-disubstituted butyrolactones in moderate yields, and allow the direct formation of a C–C bond and the construction of a lactone ring in one reaction.

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Article information

DOI: https://doi.org/10.1039/C5RA04429D
Article type: Communication
Submitted: 13 Mar 2015
Accepted: 15 Apr 2015
First published: 15 Apr 2015

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RSC Adv., 2015,5, 36167-36170

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Mn(OAc)₃-mediated arylation–lactonization of alkenoic acids: synthesis of γ,γ-disubstituted butyrolactones

Y. Gao, J. Xu, P. Zhang, H. Fang, G. Tang and Y. Zhao, RSC Adv., 2015, 5, 36167 DOI: 10.1039/C5RA04429D

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