Issue 59, 2015
From the journal:

RSC Advances

KOt-Bu/DMF promoted intramolecular cyclization of 1,1′-biphenyl aldehydes and ketones: an efficient synthesis of phenanthrenes†

Yan-yan Chen,a   Niu-niu Zhang,a   Lin-miao Ye,a   Jia-hua Chen,a   Xiang Sun,a   Xue-jing Zhanga  and  Ming Yan*a  

* Corresponding authors

a Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
E-mail: yanming@mail.sysu.edu.cn

Abstract

A new synthesis of phenanthrene derivatives has been achieved through intramolecular cyclization of 1,1′-biphenyl aldehydes and ketones promoted by KOt-Bu/DMF. A free radical reaction pathway is proposed.

Graphical abstract: KOt-Bu/DMF promoted intramolecular cyclization of 1,1′-biphenyl aldehydes and ketones: an efficient synthesis of phenanthrenes

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Article information

DOI
https://doi.org/10.1039/C5RA07188G
Article type
Communication
Submitted
21 Apr 2015
Accepted
22 May 2015
First published
22 May 2015

RSC Adv., 2015,5, 48046-48049

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KOt-Bu/DMF promoted intramolecular cyclization of 1,1′-biphenyl aldehydes and ketones: an efficient synthesis of phenanthrenes

Y. Chen, N. Zhang, L. Ye, J. Chen, X. Sun, X. Zhang and M. Yan, RSC Adv., 2015, 5, 48046 DOI: 10.1039/C5RA07188G

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