Issue 67, 2015
From the journal:

RSC Advances

Gliomasolides A–E, unusual macrolides from a sponge-derived fungus Gliomastix sp. ZSDS1-F7-2†

Jun Zhang,ac   Xiu-Ping Lin,b   Liang-Chun Li,d   Ba-Lian Zhong,c   Xiao-Jian Liao,a   Yong-Hong Liu*b  and  Shi-Hai Xu*a  

* Corresponding authors

a Department of Chemistry, Jinan University, Guangzhou 510632, P. R. China
E-mail: txush@jnu.edu.cn

b Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, P. R. China
E-mail: yonghongliu@scsio.ac.cn

c National Engineering Research Centre of Navel Orange, Gannan Normal University, Ganzhou 341000, P. R. China

d School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, 621010, Sichuan, P. R. China

Abstract

Five unusual macrolides, gliomasolides A–E (1–5), were isolated from a sponge-derived fungus Gliomastix sp. ZSDS1-F7-2. Their structures were established by extensive spectroscopic analyses and single-crystal X-ray diffraction studies. Structurally in common, these compounds feature a very rare 14-membered macrocyclic backbone lacking of methyl group. Cytotoxic effect of these metabolites against the growth of HeLa cell lines was evaluated, revealing that 1 exhibited moderate inhibitory effect with an IC50 value of 10.1 μM.

Graphical abstract: Gliomasolides A–E, unusual macrolides from a sponge-derived fungus Gliomastix sp. ZSDS1-F7-2

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Article information

DOI
https://doi.org/10.1039/C5RA08559D
Article type
Communication
Submitted
08 May 2015
Accepted
09 Jun 2015
First published
16 Jun 2015

RSC Adv., 2015,5, 54645-54648

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Gliomasolides A–E, unusual macrolides from a sponge-derived fungus Gliomastix sp. ZSDS1-F7-2

J. Zhang, X. Lin, L. Li, B. Zhong, X. Liao, Y. Liu and S. Xu, RSC Adv., 2015, 5, 54645 DOI: 10.1039/C5RA08559D

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