Issue 82, 2015

One-pot synthesis of gadolinium(iii) doped carbon dots for fluorescence/magnetic resonance bimodal imaging

Abstract

A combination of fluorescence and magnetic resonance imaging (MRI) can provide high-resolution macroscopical anatomical information and high-sensitivity microscopical optical signal simultaneously. In this work, harmless gadolinium(III) doped carbon dots are synthesized in a convenient one-pot hydrothermal approach and used for fluorescence/magnetic resonance multimodal imaging. Unlike typical carbon dots, TEM analysis shows that the carbon dots are particles with irregular shape. Furthermore, Fourier-transform infrared (FTIR) spectra demonstrated structural difference between gadolinium-undoped and doped carbon dots. Nonetheless, the gadolinium-doped carbon dots exhibit strong and stable fluorescence with excitation-dependent emission behavior. Moreover, as an MRI contrast agent, the gadolinium-doped carbon dots represent considerable magnetic resonance properties with a longitudinal relaxation rate of 14.08 mM−1 s−1. In addition, cytotoxicity study reveals that the gadolinium-doped carbon dots show very low toxicity to NCI-H446 cells with an IC50 value of 6.28 mg mL−1. Direct application in cell labeling and in vivo MRI suggests that the gadolinium-doped carbon dots are dual functional fluorescent/MRI probes with excellent biocompatibility.

Graphical abstract: One-pot synthesis of gadolinium(iii) doped carbon dots for fluorescence/magnetic resonance bimodal imaging

Supplementary files

Article information

Article type
Paper
Submitted
27 May 2015
Accepted
28 Jul 2015
First published
29 Jul 2015

RSC Adv., 2015,5, 66575-66581

One-pot synthesis of gadolinium(III) doped carbon dots for fluorescence/magnetic resonance bimodal imaging

H. Liao, Z. Wang, S. Chen, H. Wu, X. Ma and M. Tan, RSC Adv., 2015, 5, 66575 DOI: 10.1039/C5RA09948J

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