Issue 81, 2015

Selective preconcentration and online collection of charged molecules using ion concentration polarization

Abstract

A multilayer micro/nanofluidic device was presented for the selective preconcentration and online collection of charged molecules with different physicochemical properties based on ion concentration polarization phenomena. With a balance of electroosmotic drag force and electrophoretic force on the molecules, a sample mixture of sulforhodamine B and Alexa Fluor 488 could be highly preconcentrated and separated simultaneously. A repeated microchamber structure was employed to capture each dye at a desirable position. For subsequent on-chip or off-chip application, pneumatic microvalves were integrated and selectively collected the target dyes with cyclic valve operations. Using the integrated system, Alexa Fluor 488 was solely collected (with a separation resolution of 1.75) out of the mixture at a 30-fold preconcentration ratio. This integrated device would be a key component for lab on a chip applications.

Graphical abstract: Selective preconcentration and online collection of charged molecules using ion concentration polarization

Supplementary files

Article information

Article type
Paper
Submitted
30 Jun 2015
Accepted
27 Jul 2015
First published
27 Jul 2015

RSC Adv., 2015,5, 66178-66184

Selective preconcentration and online collection of charged molecules using ion concentration polarization

J. Choi, K. Huh, D. J. Moon, H. Lee, S. Y. Son, K. Kim, H. C. Kim, J. Chae, G. Y. Sung, H. Kim, J. W. Hong and S. J. Kim, RSC Adv., 2015, 5, 66178 DOI: 10.1039/C5RA12639H

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