Issue 96, 2015

Mild Cu(OAc)2·H2O-catalyzed synthesis of multi-substituted 1,2,4-triazoles from amidines with nitriles via a N–N/C–N coupling

Abstract

A simple and efficient Cu(OAc)2·H2O-catalyzed aerobic oxidation of amidines with nitriles for the synthesis of multi-substituted 1,2,4-triazoles has been achieved. The procedure constructs multi-substituted 1,2,4-triazoles and has the advantages of operational simplicity, broad substrate scope, and no need for prefunctionalized reagents. A possible mechanism has been proposed via the cascade N–H functionalization and N–N/C–N bond formation.

Graphical abstract: Mild Cu(OAc)2·H2O-catalyzed synthesis of multi-substituted 1,2,4-triazoles from amidines with nitriles via a N–N/C–N coupling

Supplementary files

Article information

Article type
Paper
Submitted
08 Aug 2015
Accepted
03 Sep 2015
First published
03 Sep 2015

RSC Adv., 2015,5, 78422-78426

Author version available

Mild Cu(OAc)2·H2O-catalyzed synthesis of multi-substituted 1,2,4-triazoles from amidines with nitriles via a N–N/C–N coupling

F. Wang, Q. You, C. Wu, D. Min, T. Shi, Y. Kong and W. Zhang, RSC Adv., 2015, 5, 78422 DOI: 10.1039/C5RA15919A

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