Issue 103, 2015
From the journal:

RSC Advances

Resorufin based fluorescence ‘turn-on’ chemodosimeter probe for nitroxyl (HNO)†

Kondapa Naidu Bobba,‡a   Ying Zhou,‡b   Lin E. Guo,b   Tie Nan Zang,b   Jun Feng Zhang*c  and  Sankarprasad Bhuniya*ad  

* Corresponding authors

a Amrita Centre for Industrial Research & Innovation, Amrita Vishwa Vidyapeetham, Ettimadai, Coimbatore 641112, India
E-mail: b_sankarprasad@cb.amrita.edu

b Key Laboratory of Medicinal Chemistry for Natural Resource, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China

c College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China
E-mail: junfengzhang78@aliyun.com

d Department of Chemical Engineering & Materials Science, Amrita Vishwa Vidyapeetham, Ettimadai, Coimbatore 641112, India

Abstract

A cellular responsive, highly selective fluorogenic and chromogenic chemodosimeter probe for HNO is developed. This new probe showed ∼30 fold fluorescence enhancement in the presence of HNO and is sensitive to HNO at concentrations as low as 0.02 μM. Further, it is capable of detecting HNO levels in cellular milieus as well as in live specimens e.g. C. elegans.

Graphical abstract: Resorufin based fluorescence ‘turn-on’ chemodosimeter probe for nitroxyl (HNO)

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Article information

DOI
https://doi.org/10.1039/C5RA17837A
Article type
Communication
Submitted
02 Sep 2015
Accepted
30 Sep 2015
First published
01 Oct 2015

RSC Adv., 2015,5, 84543-84546

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Resorufin based fluorescence ‘turn-on’ chemodosimeter probe for nitroxyl (HNO)

K. N. Bobba, Y. Zhou, L. E. Guo, T. N. Zang, J. F. Zhang and S. Bhuniya, RSC Adv., 2015, 5, 84543 DOI: 10.1039/C5RA17837A

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